Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes.

• Tác giả: Sandra Algaze, Karam Ashouri, Yasmine Baca, Francesca Battaglin, Alex Farrell, Sanjay Goel, Richard M Goldberg, Priya Jayachandran, Heinz-Josef Lenz, Jae Ho Lo, Emil Lou, John L Marshall, Pooja Mittal, Anthony F Shields, Indrakant K Singh, Shivani Soni, Lesly Torres-Gonzalez, Benjamin A Weinberg, Alexandra Wong, Joanne Xiu, Jian Yu, Lin Zhang, Wu Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 912.01 Philosophy and theory
• Thông tin xuất bản: United States : International journal of cancer , 2025
• Bộ sưu tập: NCBI
• ID: 61653

Tóm tắt

 Myeloid cell leukemia 1 (MCL-1) is a member of the B-cell lymphoma 2 protein family and has anti-apoptotic functions. Deregulation of MCL-1 has been reported in several cancers, including lung and breast cancer. In the present study, the association of MCL-1 expression with molecular features in colorectal cancer (CRC) has been highlighted. CRC samples from Caris Life Sciences (Phoenix, AZ) were analyzed using NextGen DNA sequencing, whole transcriptome sequencing, whole exome sequencing, and immunohistochemistry (IHC)
  and stratified based on MCL-1 expression as top quartile MCL-1