Cytoplasmic flow is a cell size sensor that scales anaphase.

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Tác giả: Olga Afonso, Ludovic Dumoulin, Marcos Gonzalez-Gaitan, Karsten Kruse

Ngôn ngữ: eng

Ký hiệu phân loại: 532.56 Flow when pressure is variable

Thông tin xuất bản: England : Nature cell biology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 61721

During early embryogenesis, fast mitotic cycles without interphase lead to a decrease in cell size, while scaling mechanisms must keep cellular structures proportional to cell size. For instance, as cells become smaller, if the position of nuclear envelope reformation (NER) did not adapt, NER would have to occur beyond the cell boundary. Here we found that NER position in anaphase scales with cell size via changes in chromosome motility, mediated by cytoplasmic flows that themselves scale with cell size. Flows are a consequence of friction between viscous cytoplasm and bulky cargo transported by dynein on astral microtubules. As an emerging property, confinement in cells of different sizes yields scaling of cytoplasmic flows. Thus, flows behave like a cell geometry sensor: astral microtubules approach the boundary causing flow velocity changes, which then affect the velocity of chromosome separation, thus scaling NER.
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