INTRODUCTION: Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca METHODS: Cerebral arteries from 5x-FAD and wild-type (WT) littermates were used for molecular biology, electrophysiology, ex vivo, and in vivo experiments. RESULTS: Arterial BK DISCUSSION: Our data highlight the central role played by BK HIGHLIGHTS: Cerebral microvascular BK