Two Coupled Continuous-Flow Ventricular Assist Devices as a Novel BIVAD With One Driveline: Acute Animal Study Results.

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Tác giả: Johann Bauersachs, Dominik Berliner, Ezin Deniz, Günes Dogan, Jasmin Hanke, Torsten Heilmann, Sara Knigge, Fanwu Kong, Ali Merzah, Aron F Popov, Arjang Ruhparwar, Bastian Schmack, Jan D Schmitto, Alexander Weymann

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Artificial organs , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 618938

BACKGROUND: The study assesses the feasibility of the DuoCor BiVAS, a novel biventricular assist system integrating magnetic levitation technology. METHODS: In an acute large animal model involving five sheep, each received the DuoCor BiVAS without cardiopulmonary bypass. Hemodynamic and device parameters were monitored continuously for 1-h post-implantation. RESULTS: Intraoperative implantation was uneventful, demonstrating successful biventricular support with mean blood flows of 5.4 LPM (left) and 5.5 LPM (right). Analysis showed proportional flow rates and relationships between pump speed, flow, and power consumption. No adverse events like thrombus formation, bleeding, stroke, or device failure occurred. CONCLUSION: This research underscores the DuoCor BiVAS's potential for severe biventricular heart failure treatment, providing insights into its feasibility and functionality in acute animal models. The findings suggest promising clinical applications, particularly with the system's single driveline design potentially enhancing patient mobilization and quality of life. Further investigations are needed to advance this technology for broader clinical use.
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