The additional bacteria that were found in pigs suspected mycoplasmosis include Pasteurella multocida. Staphylococcus spp., Streptococcus spp., Haemophilus parasuis, EscherichIa coli and Klebsiella pneumoniae. Results of testing sensitivity to antibiotics of some bacterial isolates showed that two antibiotics Ofloxacin and Cefotaxime have broad antibacterial spectrum, affecting many different bacterial communities developed. Two of Pfizer products Draxxin and Excede are highly effective in the treatment of mycoplasmosis in pigs. Cure rate ranges from 91.63 percent to 91.84 percent. Mycoplasmosis prevention process may include the use of vaccine or without vaccine application. However. both processes must meet the general principles of animal husbandry as limiting the visit. using the all in - all out, etc.