Metabolic bone disease might commence early in the course of renal failure. This study therefore examined the frequency and severity of the skeletal changes male patients with chronic kidney disease stage III and IV by measurements of bone mineral density (BMD), biochemical markers of bone parathyroid hormone (PTH), ionized calcium (Ca++), and glomerular filtration rate (GFR). The patients had significantly (p 0.05) reduced BMD in the spine (51.2 percent
the femur (57.5 percent,). All of the measured bone markers showed increasing plasma levels with the more advanced stages of renal failure. Serum PTH serum levels increased. BMD Z-scores of the femur correlated to the biochemical markers as: to PTH (r (