Anterolateral thigh flap (ALT flap) was first found and used by Song in 1984. Classified in the perforator type flaps, ALT flap is blood supplied by the perforators of the descending branch of the lateral circumflex thigh artery. The flap is the first choice in many cases, those need a large soft tissue for reconstruction, especially in the cervicofacial area thanks to many advantages of the flap: constants and relievable anatomic structure, large blood supply, flexible in use as well as other advantages. From 1/2006 to 9/2010, 34 ALT flaps were used for patients with soft tissue defects in cervico facial area. The outcome is considerable with the main following conclusions: The flap is harvested relatively easy in clinical practice. The use of the ALT flap is flexible with good result in reconstruction of soft tissue defects in cervico facial area.