Anterolateral thigh flap (ALT) based on descending branch of the lateral circumflex femoral is widely used for reconstructive surgery of surface defects in the body. However, studies of the anatomy of this flap especially are still not interested. The study aims to learn the characteristics of vascular anatomy of descending branch of the lateral circumflex femoral in Vietnamese population and reviewed the surgical characteristics of vascular anatomy of ALT in practice. Results show that 100 percent specimens have main descending branch. Perforator from main descending branch is 69.15 percent. Perforator from from descending branch focus in period 8 and 9 equivalent center circle. The lateral superior genicular artery has average diameter 2.16mm. Descending branch of the lateral circumflex femoral always combine with lateral superior genicular artery at the top of patella. Place of linking between descending branch and the lateral superior genicular artery far from baseline (at the bottom) 6.4 + or - 2.56cm. In conclusion, the vascular artery of the flap is almost consistently. Therefore, it is very convenient to using the distally based ALT flap.