Thalassemia is a congenital hemolytic disorder caused by a partial or complete deficiency of alpha or beta globin chain synthesis. The patients with beta thalassemia major (beta - TM) suffer from severe anemia and other serious complications from early childhood. The patients with beta thalassemia intermedia (beta - TI) need blood transfusion less than beta - TM. As a consequence, complications could be recognized later. There are many reports about thromboembolic complications in thalassemia in the world. From December 2010 to January 2011, th authors performed 119 cases of beta - TI for plalete count, Prothrombin time, INR, rAPTT, rTT and 55 case for platelet aggregation adenosine diphosphate (ADP), collagen, ristocetin, and evaluation IIa, Va, Vila, Xa, vWF, vWFa, ATIII, Protein C (PC), Protein S (PS) and D dimmer. The authors found that 90 percent patients who undergone splenectomy had high platelet counts. However defective platelet aggregation in response to ADP in 85.45 percent patients, to Collagen in 47.27 percent patients and to Ristocetin in 72.73 percent patients with beta - TI. Prothrombin time (PT percent) is low in 42 percent patients. Levels of factors II, V, VII, X are among 43 percent - 120 percent. They are similar between splenectomy patients group and non splenectomy group (p 0.05). Low levels of the coagulation inhibitors - protein C (PC) found in 43.64 percent patient and protein S (PS) found in 16.36 percent. Level of ATIII is in normal range. High plasma D-dimer levels (240 - 500 mg/l) are detected in 28.31 percent and 6.67 percent patients had plasma D-dimer levels over 500 mg/l. There is difference between splenectomy patients group and non splenectomy group (p 0,05).