Rheumatoid arthritis is the most common in the group of chronic arthritis in aldults. The diesease is considered a disease of the affliate system by autoimmunity. The cause is not yet cear, it was found that there are many factors involved in pathogenesis of rheumatoid arthritis, which plays a very important role of the inflammatory cytokine, especially is IL-6 secreted by macrophages and synovial cells. Subjects and Methods: Determine the correlation between levels of serum IL -6 whith clinical factors: disease duration, the number of damaged joint as well as clinical factor: RF, CRP, VS and Fibrinogen in patients whith rheumatoid arthritis. Subject and methods: The research 42 patients with rheumatoid arthritis was diagnosed according to ACR 1987, were examined to determine the disease duration as well as the number of damaged joints, take quantitative blood and serum concentrations of IL-6, RF, CRP, fibrinogen and VS. Result: The average of IL-6 serum concentrations in patients with rheumatoid arthritis is 36.4 pg/ml. IL-6 has both positive correlation with the disease duration, r = 0.425
IL-6 correlated closely agree with the number of damaged joints, r = 0.617. Considering the correlation with clinical factors: IL-6 has positive correlation with both CRP r = 0.407, with VS after an hours r = 0.467, with VS after two hours r = 0.386. IL-6 correlated closely agree with Fibrinogen, r = 0.748 and not see a correlation with RF. Conclusion: IL-6 serum concentrations of patients with rheumatoid arthritis have positive correlation with moderate elements disease duration, CRP, VS after one hour, after two hours and a positive correlation quite closely with the number of damaged joints as well as Fibrinogen, have not seen a correlation with RF.