Neonatal sepsis is invasive infection, usually bacterial, occurring during the neonatal period. Methods: Records 50 of infants with positive blood cultures obtained while they were inpatients in the Neonatal Unit at Viet Nam-Cuba Dong Hoi Friendship Hospital from january 1, 2010 to december 31, 2010 were reviewed retrospectively. Results: The overall percentage of sepsis caused by Citrobacter was the predominant organism cultured (52.83 percent), followed by Staphylococcus aureus (28.30 percent), E.coli (7.55 percent) and Enterobacter (7.55 percent). Preferable antibiotics for neonatal sepsis: 100 percent Citrobacter were sensitive to Ofloxacin
74.07 percent were sensitive to Imipenem. 93.33 percent S. Aureus were sensitive to Imipenem
85.71 percent were sensitive to Amoxycillin + Clavulanic acid. A mortality rate as a result of sepsis of 21.57 percent. Conclusions: Common cause: Citrobacter and S. Aureus. Preferable antibiotic: Imipenem.