Hspa13 Deficiency Impaired Marginal Zone B Cells Regulatory Function and Contributed to Lupus Pathogenesis.

• Tác giả: Haoran Cui, Xin Huang, Ge Li, Kun Liu, Xiaoling Liu, Lun Song, Renxi Wang, Qing Wen, Chen Xing
• Ngôn ngữ: eng
• Ký hiệu phân loại: 371.911 *Students with blindness and visual impairments
• Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 622350

Tóm tắt

Dysregulated IL-10 producing regulatory B cells (Bregs) are associated with the progression of systemic lupus erythematosus. An immunomodulatory role of heat shock proteins (HSPs) is implicated in autoimmune diseases. However, the molecular basis underlying the role of Hspa13 in regulating Bregs function and lupus pathogenesis remains unclear. In this study, Bregs display higher Hspa13 expression than IL-10