Objective of the study was to assess the effects of single He-Ne laser therapy and combined laser-antibiotic therapy on the structural regeneration of rabbits' cornea ulcerated by staphylococcus infection. Method: Using the rabbits' ulcerated corneal model by Staphylococcus infection, then treating 5-10-15 day periods by He-Ne laser irradiation (power density: 2 mW/sq. cm, daily) and by the combined He-Ne laser-antibiotic therapy (0.4 percent chlorocide solution in situ). In conclusions: (1) The therapeutics promoted the micro structural regeneration of ulcerated cornea more rapidly than in control. (2) There was no difference between two therapeutics' results. The time of treatment evaluated at 15 days reviewed. (3) Laser irradiation acted to exclude necrobiosis and decrease local inflammation quickly, stimulate the structural regeneration of cornea ulcerated and promote the healing of wound.