Bolivmed is the product prepared from Phyllanthus urinaria L. and Cratoxylon prunifolium materials that meet Institutional Standard, has been investigated about safety and pharmacological effects. This report presents about the investigational results of the hepato-protective effects on experiment. The results showed that Bolivmed capsule reduced serum ALT and AST, reduced hepatic MDA, enhanced GSH in the liver, reduced the hepatitis, and reduced the hepatic injury on CO4 -toxicated mice model. This result showed to be equivalent to those effects of Eganin on CO4 -toxicated mice model.