Carpal tunnel syndrome (CTS) is the most common mononeuropathy in patients with end-stage kidney disease (ESKD). The diagnosis of CTS was established by the clinical features and electrophysiological studies. Objective: To study clinical features and electrophysiological parametters of the CTS in the patients with ESKD on hemodialysis (HD). Materials and Methods: Clinical internal-neurologic and electrophysiologic investigations in median nerves were performed in 95 HD patients and 97 healthy. Results. On clinical evaluation, 23.2 percent patients were categorized as having clinical CTS in the patients on HD such as numbness of lateral four fingers, abductor pollicis brevis weakness, hypesthesia of median nerve distribution, Tinel sign. Based on the electrophysiological studies, 30 out of 95 (31.6 percent) patients on HD were classified with a CTS. The frequencies of CTS according to the side of fistula in patients on HD were 17.9 percent in the both sites, 10.5 percent in the left and 3.2 percent in the right site. Conclusions. The electrophysiological findings (31.6 percent) are more objective than the clinical sympt.oms and/or signs (23.2 percent). The frequency of CTS was not different between the hand with an arteri ovenous fistula and the contralateral hand.