Purpose: This prospective study investigated the effect of CRRT (Continuous Renal Replacement Therapy) on 51 severely burned patients admitted to Burned ICU National Institute of Burns from 1/2004 to 1/2008. Methods: The use of two techniques: continuous veno - venous hemofiltration and continuous veno - venous hemofiltration dialysis. Results : The result showed that after CRRT, the plasma concentration of pro inflamatory cytokine including IL6, IL8 and TNFa significantly decreased (p 0.01). In addition, the clinical improvement amounted to 50/51 patients (98.04 percent), and the mortality rate was 45.1 percent.