Background: Grave's disease (GO) is an autoimmunology disease with hypervasculisation of thyroide gland. Sometimes, the treatment by endoscopic surgery is difficult because of severe bleeding. The author report experience in treatment of Grave's disease by total endoscopy surgery. Patients and Methods: Data were collected perspectively on 55 patients with thyroidectomy by endoscopic surgery performed for GO from September 2003 to June 2010. This included patients demographics, type of surgery performed, operative time, rate of conversion to open surgery, intra and postoperative complication and thyroid status. The procedure was purely endoscopic thyroidectomy with carbon dioxide insufflation. All of patients were in euthyroidism status and have been prepared preoperatively by 1 percent Lugol solution. The type of surgery included nearly total thyroidectomy with thyroid remnant of 4- 6grams, total thyroidectomy or Dunhill operation. Total thyroidectomy was performed for concormitant nodule, severe ophtalmopathy, allergy to anti thyroid medication. Results: There were 53 women (96.4 percent) and 2 men (3.6 percent) with average age of 29.5 years (16-55). The mean thyroid volume was 25ml (18-41). Total thyroidectomy, nearly-total thyroidectomy and Dunhill operation were in 17 cases (30.9 percent), 35 cases (63.6 percent), and 3 cases (5.5 percent) respectively. The mean operation time was 125.6 minutes (80-280). In the first period, there were 3 cases converted to open surgery because of severe bleeding, 1 case of tracheal perforation (caused by using the harmonic scalpel) which had been recovered by postoperative continuous aspiration in 3 days. Postoperative complications: Temporary hypoparathyroidism, and horseness were in 5 cases, and 2 cases respectively. There was no case of permanent recurrent laryngeal palsy. Postoperative reexamination for 24 (68.6 percent) patients of nearly total thyroidectomy who were followed- up at 6 months showed that 23 patients were in euthyroid status with mean thyroid remnant of 4,7g and 1 patient in hypothyroidism requiring lifelong thyroxine. Conclusions : Endoscopic thyroidectomy can be performed safety, effectively for Grave's diease . Most of near total thyroidectomy are in post-operative euthyroidism status.