Đột biến gen p53 liên quan đến ung thư gan trên bệnh nhân nhiễm virut viêm gan b

• Tác giả: Hữu Song Lê, Thị Kim Chinh Nguyễn, Trọng Chính Nguyễn
• Ngôn ngữ: vie
• Ký hiệu phân loại: 616.99 Tumors and miscellaneous communicable diseases
• Thông tin xuất bản: Tạp chí Y Dược lâm sàng 108, 2011
• Mô tả vật lý: 116-120
• Bộ sưu tập: Metadata
• ID: 625477

Tóm tắt

Background: p53 gene mutation has been demonstrated to be associated with the progression of hepatocellular carcinoma (HCC). Aims: To investigate the relationship between p53 gene mutation with HCC in patients infected with hepatitis B virus (HBV). Subjects: 94 HCC patients infected with HBV and 100 healthy control were enrolled in this study. Methods: p53 gene mutation was identified by PCR-RFLP. Results: p53 gene mutation at codon 249 (Arginine - Serine) was found in 15/194 (7.73 percent) cases. This mutation was seen more frequently in HCC patients than in healthy control (12.7 percent vs 3 percent, p 0.05). This mutation is associated with the progression of HCC (OR (95 percent CI)