Purpose: To determine the efficacy of vitrectomy for retinal detachment due to open-globe injury with using endoscope. Objectives and methods: a prospective clinical intervention study without control group on 71 consecutive eyes with retinal detachment due to open-globe injury. There are 4 surgical procedures: 1. vitrectomy with internal tamponade by gaz, 2. vitrectomy, gaz internal tamponade and scleral buckling, 3. vitrectomy with silicon oil internal tamponade, 4. vitrectomy with silicon oil internal tamponade and scleral buckling. Results: Silicon oil was used in 87.3 percent cases. Additional buckle was used in 15.6 percent cases. The rate of retinal well reattach ranges from 69.6 percent to 71.8 percent. Main reason of recurrent is vitreoretinal proliferation which ranges from 29.6 percent to 42.3 percent. Thanks to endoscope, vitreoretinal incarceration complication reduces to 3.55 percent. Conclusions: Using endoscope in vitrectomy for retinal detachment due to open-globe injury is effective and safe procedure.