Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein.

• Tác giả: Surl-Hee Ahn, Slava Bekker, Colleen E Clancy, John R D Dawson, Kevin R DeMarco, Yanxiao Han, Khoa Ngo, Kyle C Rouen, Igor Vorobyov, Yang K Xiang, Vladimir Yarov-Yarovoy
• Ngôn ngữ: eng
• Ký hiệu phân loại: 664.001579 Food technology
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 62585

Tóm tắt

G protein-coupled receptors (GPCRs) and G proteins transmit signals from hormones and neurotransmitters across cell membranes, initiating downstream signaling and modulating cellular behavior. Using advanced computer modeling and simulation, we identified atomistic-level structural, dynamic, and energetic mechanisms of norepinephrine (NE) and stimulatory G protein (G