Three field experiments were conducted to evaluate effect of microbial compost (MC) on yield and quality of three kinds of leaf-eating vegetable (spinach, basella-alba and lettuce) grown on alluvial soil of Song Hau farm (Co Do district - Can Tho city). Three experiments were randomized complete block design with four treaments and three replications. The treament 1 [no inorganic fertilizer and microbial compost], treatment 2 [100 N - 80 P2O5 - 40 K20 kg/ha], treatment 3 [1000 kg/ha microbial compost] and treatment 4 [1000 microbial-compost plus 50 N - 40 P2O5 - 20 K20 kg/ha]. The results showed that fresh yield of treatment 3 (1000 microbial-compost plus 50 N - 40 P2O5 - 20 Kp kg/ha) in spinach, basella-alba and lettuce did not differ with fresh yield of treatment 2 (100 N - 80 P2O5 - 40 K2O kg/ha) but nitrate content in leaves of three kinds of vegetable was low, therefore application of 1000 kg MC/ha saved up 50 percent amount of chemical fertilizer. Analysis of economical benefit showed that applying MC together with half quantity of inorganic fertilizer in spinach, basella-alba and lettuce cultivation (the first cropping- season) were the highest income. Application of MC in spinach, basella-alba and lettuce cultivation not only saved half amount of chemical fertizer for vegatable cultivation but also kept quality product (low nitrate content in leaves).