A disease complex due to root-knot nematode and soil-borne fungi (Sclerotium rolfsii, Rhizoctonia solani) was studied in tomato. There was significant difference about root galls and egg-masses of transgenic tomatoes in comparison to control with non-transgenic tomatoes. The level of resistance was partial (P) and resistant (R) for transgenic tomato. In contrast, non-transgenic tomatoes were showed at the susceptible (5) and partial (P). Application of the organic product (Oligosaccharide 0.2 percent, LEG 0.02 percent) increased plant growth, and reduced galling, nematode multiplication, root-knot index and less susceptible to complex disease of tomato. Oligosaccharide 0.2 percent, LEG 0.02 percent decreased the incidence of root-knot nematode and complex disease M. incognita-R. solani, M. incognita-S. rolfsii, however, they were more effective against root-knot nematode than soil-borne fungi. Application of induced resistance factors, original from inorganic matters such as, BION, CuCl2 and SA or organic origin as antagonistic fungi in controlling plant diseases is promising way because they are quite friendly with environment and safe for human and animals using agricultural products. In Vietnam, induced resistance factors are not used popularly. The experiments were carried out in greenhouse to determine some effective induced resistance factors and when induced resistance factors treated is good to reach the highest efficacy in controlling disease complexes, M. incognita-R. solani and M. incognita-S. rolfsii.