Nghiên cứu bào chế pellet itraconazol bằng phương pháp bao tầng sôi

• Tác giả: Đăng Hoà Nguyễn, Thị Hải Quỳnh Nguyễn, Văn Long Nguyễn, Trịnh Công Trần
• Ngôn ngữ: vie
• Ký hiệu phân loại: 615.19 Pharmaceutical chemistry
• Thông tin xuất bản: Tạp chí Dược học, 2012
• Mô tả vật lý: 17-20
• Bộ sưu tập: Metadata
• ID: 627280

Tóm tắt

 The pellets of itraconazole were prepared in hydroxypropylmethyl-cellulose E6 (HPMC) with addition of Tween 80 on sugar spheres using a fluidized-bed coating system. A mixture of dichloromethane and ethanol (3:2
  w/w) was found suitable as spraying solution for simultaneous application of itraconazole, HPMC and Tween 80. The obtained pellets were characterized by differential scanning calorimetry (OSC), X-ray diffractometry (XRO) , infrared spectroscopy (IR) and dissolution tests. The pellets showed a dissolution profiie 'similar to that of reference capsule Sporal and the method could be applicable to one-step encapsulation.