Genetic variants of accessory proteins and G proteins in human genetic disease.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Peter Chidiac, Caroline M Gorvin, Alexander S Hauser, Pedro A Jose, Miles D Thompson

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Critical reviews in clinical laboratory sciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 627489

 We present a series of three articles on the genetics and pharmacogenetics of G protein- coupled receptors (GPCR). In the first article, we discuss genetic variants of the G protein subunits and accessory proteins that are associated with human phenotypes
  in the second article, we build upon this to discuss "G protein-coupled receptor (GPCR) gene variants and human genetic disease" and in the third article, we survey "G protein-coupled receptor pharmacogenomics". In the present article, we review the processes of ligand binding, GPCR activation, inactivation, and receptor trafficking to the membrane in the context of human genetic disease resulting from pathogenic variants of accessory proteins and G proteins. Pathogenic variants of the genes encoding G protein α and β subunits are examined in diverse phenotypes. Variants in the genes encoding accessory proteins that modify or organize G protein coupling have been associated with disease
  these include the contribution of variants of the regulator of G protein signaling (RGS) to hypertension
  the role of variants of activator of G protein signaling type III in phenotypes such as hypoxia
  the contribution of variation at the
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH