That itraconazole (lTZ) commonly used as an antifungal agent of broad spectrum of activity, but of extremely poor solubility initiated this study to improve its dissolution rate by forming a complex with 2-hydroxypropyl-beta-cyclodextrin (HPBCD). The process was quantitatively validated proving to meet requirements for linearity (8-28 ug/ml), precision (RSD 2 percent) and accuracy (80-110 percent). The proportion between ITZ and HPBCD of 1:2 was best suitable. Dissolution tests showed the complex containing the 5 percent of additive K prepared by kneading (40 min) had a significantly high dissolution rate (79.4 percent after 60 min). Moreover, changes were recorded in its spectra (lR, DSC, 1H-NMR) and melting point. Also, capsules containing ITZ-HPBCD complex had much better dissolution rate (76.56 percent after 45 min).