From cheap materials available in Vietnam such as 4-chlorobenzoic acid, anisole, aluminium chlorid... 4-chloro-4'-hydroxybenzophenon was synthesized to use as an important material in synthesis of the most common blood triglycerides-reducing drug, fenofibrate by name. The synthesis was optimized by the software MODE 5.0 for technical consistency, simplicity and suitability for Vietnam's conditions.