Some derivatives of benzimidazole were successfully synthesized. Their purities and structures were characterized by melting point, thin layer chromatography and IR, MS, 1H-NMR, 13C-NMR spectra. The influences of the obtained compounds on the activity of cancer cells including liver cancer (Hep-G2) and lung cancer (Lu), were investigated. Notwithstanding, the experimental anticancer activity was not significant.