Nghiên cứu bào chế viên nén acyclivir kết dính sinh học đặt phụ khoa giải phóng kéo dài 12 giờ

• Tác giả: Thị Minh Huệ Phạm, Thị Thuý Nga Trần, Thị Thu Giang Vũ
• Ngôn ngữ: vie
• Ký hiệu phân loại: 615.13 Formularies
• Thông tin xuất bản: Dược học, 2012
• Mô tả vật lý: 40-43
• Bộ sưu tập: Metadata
• ID: 627701

Tóm tắt

Novel sustained-release bioadhesive vaginal tablets of Acyclovir 200 mg were developed. The developed formulation showed the ACV release and bioadhesion properties of the tablets were controllable by changing each and/or both the type and concentration of polymer excipients. Carbopol 934P and hydroxy propyl methyl cellulose E6 were chosen as candidate bioadhesive polymers. The swelling behavior, bioadhesive strength and in vitro release of the prepared tablets were investigated. The results suggested that the main factor affecting the release rate of acyclovir and bioadhesive strength was the amount of Carbopol 934P. The optimal formula of bioadhesive tablets of Acyclovir was able of sustaining the ACV release up to 12 hours was chosen. Bioadhesion of the developed formulations would assure a longer period of reslaence time, to offer better therapy availability.