Nghiên cứu điều chế và ứng dụng zein làm tá dược bào chế thuốc giải phóng kéo dài

• Tác giả: Thị Ngọc Hân Đào, Thị Hải Bình Định, Văn Hải Nguyễn, Văn Lẩu Trịnh
• Ngôn ngữ: vie
• Ký hiệu phân loại: 615.1 Drugs (Materia medica)
• Thông tin xuất bản: Dược học, 2012
• Mô tả vật lý: 49-51
• Bộ sưu tập: Metadata
• ID: 627703

Tóm tắt

Zein was produced from corn powder by multiple stage extraction with ethanol. Oils, fats and other impurities were removed by n-hecxane. The crude zein was decolorized by active charcoal as adsorbent. Spray-drying to remove the solvent yieded refined zein. The the obtained product met some specification requirements by USP30. The extended-release tablets of pseudoephedrine coated with the obtained zein proved controllable of the drug release in different media. The prepared zein showed useful for making film-coat of sustained release dosage forms.