Ảnh hưởng của điều kiện oxy thấp và đường cao lên kênh na trên màng tế bào thần kinh hạch rễ lưng

• Tác giả: văn Mại Hoàng, Xuân Thiệu Phan, Thị Bích Hoài Tôn
• Ngôn ngữ: vie
• Ký hiệu phân loại: 612.82 Brain
• Thông tin xuất bản: TC Sinh học, 2012
• Mô tả vật lý: 127-132
• Bộ sưu tập: Metadata
• ID: 628316

Tóm tắt

Hypoxia and hyperglycemia are considered as the leading causative factors of diabetes and frequently associated with several complications. Voltage-gated sodium channels are large trans-membrane proteins that contribute to the initiation and propagation of neuronal excitability associated with pain. The study show that hypoxic and high glucose cellular environment increases the excitability of DRG neurons by increasing amplitude and decreasing duration of action potentials. Na conductance of TTX-S sodium channels increased under the experimental condition that induces the Na gates close and open faster, without affecting the level of genes expression. These data indicate that TTX-S Na current is modulated under hypoxic and high glucose conditions, which might be relevant for diabetes-related complications or other diseases associated with acute hypoxia and hyperglicemia.