The research conducted to survey, compare the features in multinubient accumulation of flue cured tobaccos between material areas differing in quality. Flue cured tobacco production on silt loam soils or clay loam soils in Cao Bang province have made the quality of tobacco materials (Colour, aroma, tast, ...) being better than thoses have being made on infertile soils in Cao Bang or Bac Giang. Multinubient accumulation of high quality flue cured tobacco materials is following features: Content Ca, Mg and B is more high together with content CI, Fe, Mn and Cu is more low. The results in this study has been scientific base to establish a fertilizer regime being able to improve quality of fue cured tobacco on northern infertile soils.