Background: Immune thrombocytopenic purpura (ITP) is one of the most common hematologic disease in children. The treatment of chronic ITP with splenectomy is still controversial. Objective: To evaluate the effectiveness of splenectomy in the treatment of childhood chronic ITP at Ho Chi Minh city Blood transfusionHematology Hospital in 5 years time from 1/2007 to 12/2012. Subjects. and Methods: Retrospectively through 34 medical records, chronic lIP treated with laparoscopic splenectomy method. Results: The complete remission early after splenectomy approximately 79.4 percent, 5 cases of failure, accounting for 14.8 percent. one case appeared nonspecific pneumonia due to Chlamydia pneumoniae, accounting for 2.94 percent, while 97.06 percent of patients without any other complications after surgery. Conclusion: Splenectomy in treatment of chronic ITP has high complete remission as well as relatively safe, helping patients to reduce side effects due to long-term medication.