Bước đầu nghiên cứu gen npm1 - muta và flt3-itd trên bệnh nhân lơxêmi cấp dòng tủy

• Tác giả: Thị Vân Anh Kiều, Thiên Lữ Nguyễn, Quang Vinh Phạm, Minh Phương Vũ
• Ngôn ngữ: vie
• Ký hiệu phân loại: 616.155 Diseases
• Thông tin xuất bản: Tạp chí Y học Việt Nam, 2012
• Mô tả vật lý: 64-68
• Bộ sưu tập: Metadata
• ID: 629543

Tóm tắt

FLT3-ITD gene and NPM1-MutA gene have an important role in diagnosis and prognosis in acute myeloid leukemia (AML). Objective: To initially determine the expression of FLT3-ITD and NPM1-MutA genes in acute myeloid leukemia. Patients and methods: 36 patients with acute myelogenous leukemia were studied. DNA were extracted from leukemic cells and Semi-Nested ASO-PCR for NPM1-MutA and FLT3-ITD genes was done. Results and conclusions: FLT3-ITD was found in 8/36 (22.22 percent) with normal karyotype 22.22 percent. NPM1-MutA was found in 6/36 (16.17 percent) with normal karyotype 22.22 percent.