Introdudion: MISS in spine is that specifically attemps to minimize tissue damage. In Viet Duc Hospital, MISS took effect in patients with more advantages compared to traditional operation. Methods: Summary all types of MISS based on the results in Spinal department in Viet Duc hospital, included: transforaminal endoscopic discectomy, lumbar microdiscectomy using METRx, TLIF with SEXTANT system and kyphoplasty. Results: Most of patients got the quick recovery, satisfaction post operation and reduce the hospital time also. Conclusions: MISS with a lot of advantages for patients can be used for all part of spine as cervical, thoracic and lumbar also. So it gonna be the trend of development in spinal surgery not only in Viet Nam but also all over the world.