A benzofuran glycoside, 2R, 3R-2,3-dihydro-2-(4 '-hydroxy-3 '-methoxyphenyl)-3-(glucosyloxymethyl)-7-methoxy-benzofuran-5-propanol (1), was isolated for the first time from the pericarp of Garcinia mangostana. Its structure was determined by spectroscopic data in comparison with those reported in literature. The antioxidant activity of the isolated compound was evaluated by its scavenging capacity of DPPH (1,1-diphenyl-2-picrylhydrazyl) radical. Compound 1 showed significant DPPH scavenging activity with the SC50 value of 95.5 ug/ml.