Sirtuin 7 Promotes Alcohol-Associated Liver Injury via Modulating Myeloid Cell Chemokine (C-C Motif) Ligand 2 Secretion through the NF-κB Signaling Pathway.

• Tác giả: Cong Ding, Yiying Gu, Zhuan Li, Gaoshuang Liang, Jinying Peng, Zhiqiang Wang, Tingzi Yu, Xiangwen Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 617.106 Nonsurgical therapy
• Thông tin xuất bản: United States : The American journal of pathology , 2025
• Bộ sưu tập: NCBI
• ID: 630438

Tóm tắt

The pathogenesis of alcohol-associated liver disease (ALD) involves ethanol-induced enhancement of gut permeability, bacterial products released from intestine and intrahepatic inflammation, and liver damage. Hepatic macrophages play a crucial role in mediating inflammatory response by alcohol. Sirtuin 7 (SIRT7), a NAD