Objectives: to describe the clinical and laboratory features of pregnant women with hepatitis B at National hospital of obstetrics and gynecology and list some complications of hepatitis B affecting the mother and fetus during labor. Methods: A cross-sectional retrospective research was conducted on 152 women with hepatitis B who had given birth in National hospital of obstetrics and gynecology during 6 years from January 2006 to December 2010. Results: The rate of maternal hepatitis was 0.16 percent and showed an increasing trend, the highest rate was 0.32 percent in 2009. The rate of early diagnosis and treatment before and during pregnancy reached 33.3 percent in 2010. The most common symptoms are fatigue (48.1 percentJ anorexia (52.6 percentJ jaundice (22.4 percent). Bilirubin level was high in 52 patients (34.2 percent). Elevated liver enzymes occur in 80 patients (52.6 percent). Fibrinogen level falls below 2 g/l and the rate of postpartum hemorrhage was 22.7 percent. Complications to the fetus: preterm labor (24.3 percentJ fetal distress during labor (21.1 percent), fetal death after delivery (0.7 percent). Conclusions: The clinical symptoms are not specific, diagnosis and prognosis for delivery are based on levels of liver enzymes and clotting factors.