D-08 included Fructus ruceae, Semen Bruceae, Radix Glycyrrhiza, Radix Paconniale Albae, Sepia esculenta Hoyle, Rubus alceaefo/ius Poir, Pteris multifida Poir, Radix Polyscias fruticosa and Amomum xanthioides. Which is drug used treatment for gastrointestinal disease general and gastric and duodenal ulcer in particular. For increase effectiveness kill Hp, the authors have to modifying component and creat a D-08 drug. The acute toxicity test was carried out on mice, with the maximum dose of 100 g/kg body weight. The results showed that: there was not acute toxicity and the LD50 was not determined. At a concentration of 02g/ml (double dilute concentration as excellent traditional medicine), 100 percent Hp was killed in 10 exponent 8 bacteria/ml sample.