Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities.

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Tác giả: Snur Rasool Abdullah, Rouben Aroutiounian, Tigran Harutyunyan, Bashdar Mahmud Hussen, Rayan Mazin Jaafar, Thomas Liehr, Mohammed Fatih Rasul, Majid Samsami, Mohammad Taheri

Ngôn ngữ: eng

Ký hiệu phân loại: 133.5265 Astrology

Thông tin xuất bản: Netherlands : Critical reviews in oncology/hematology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 631212

Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various cancer hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, and tissue-specific expression. These non-coding RNAs function through mechanisms such as miRNA sponging, interactions with RNA-binding proteins (RBPs), and modulating transcription and splicing. Advances in RNA sequencing and bioinformatics tools have enabled the identification and functional annotation of circRNAs across different cancer types. Clinically, circRNAs demonstrate high specificity and sensitivity in samples, offering potential as diagnostic and prognostic biomarkers. Additionally, therapeutic strategies involving circRNA mimics, inhibitors, and delivery systems are under investigation. However, their precise mechanisms remain unclear, and more clinical evidence is needed regarding their roles in cancer hallmarks. Understanding circRNAs will pave the way for novel diagnostic and therapeutic approaches, potentially improving patient outcomes.
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