Objectives: To evaluate the effects of suction sputum through bronchoscopy in Chronic Obstructive Pulmonany Disease (COPD) patients with mechanical ventilation. Determine some of the complications of bronchoscopy in COPD patients with mechanical ventilation. Research Methods: Observative research about bronchoscopy in COPD patients with mechanical ventilation. Compare clinical parameters and ABG after bronchoscopy 1 hour and chest Xray images after 24 hours. Results: Pulse, blood pressure, respiratory rate unchange after bronchoscopy. Sp02 and exhaled volume (VtE) increase, the peak airway pressure reduces after bronchoscopy 1 hour. pH, PaO2 increase and stay in the average range, PaCO2 decreases after bronchoscopy 1 hour with p 0.05. The X-ray images of the pateints are improved after 24 hours. There are. 2 patiens with bronchial mucosal bleeding (5 percent), 1 patient with mild hypotension (2,5 percent). No patient with serious complications such as respiratory failure, pneumothorax, cardiac arrhythmias. Conclusions: The clinical indecators, arterial blood gases and lung X-ray images is improved after bronchoscopy. No patient with serious complications.