Chemical insecticides are used at different times all over the world with the advantages such as low cost, easy to use, effective rapid epidemic that caused the widespread abuse of chemicals. As a result, increasing the list of species of mosquitoes resistance to chemicals. Early detection and accurate level of chemical resistance mosquitoes transmit malaria are necessary. Results assessing the chemical resistance pyrethroid group of Anopheles minimus in Tan Lac district show that. the rate sensitivity of the mosquito Anopheles minimus to test chemicals in Phu Cuong is lowest, for chemicals Lambda-cyhalothrin 0,05 percent is 82 percent and for the Alpha-cypermethrin 30mg/m2 is 81 percent. Chemicals Permethrin 0.75 percent test sensitivity of 96 percent in the mosquito Anopheles minimus in Phu Cuong. For populations of Anopheles minimus in 02 communes (Quyet Chien and Trung Hoa) sensitivity decreased to 98 percent, for with Deltamethrin chemicals 0.05 percent test, the result is still highly sensitive.