Assessment of screening rate of Plasmodium spp. in blood donors in the Hematology and Blood Transfusion Hospital of Ho Chi Minh city and 19 provinces (East and Regional Mekong Delta) in 2010 and 2011. The results showed that: The quantity of blood collected has increased every year. The number of blood donation payment to decrease for the source of remunerated donation, from 1355 turns in 2010 (0.94 percent) to 44 turns in 2011, respectively - down 96.75 percent compared with the number in 2010. The rate of volunteer donor increased is increasing. The quality of apheresis donors increased every year, but the most of them are donor remuneration, the volunteer donors are still limited. Number of blood donors is 649 204 units in all districts, province in Ho Chi Minh city and some provinces such as Binh Duong, Bien Hoa,