The human hippocampal formation plays an important role in learning and memory. In rodents, hippocampal pyramidal cells have place fields in an environment, which are affected by cues and landmarks in the environment. In this study, the authors recorded neuronal activity of hippocampal place cells in C57BL/6 mice and evaluated their activities when proximal and distal cues and landmarks in familiar and novel environments changed. The result showed that hippocampal neurons in mice integrated information from both distal and proximal cues in the environment, suggesting a role of the hippocampus in spatial learning and memory.