Objective: Assess the efficacy and effectiveness of early micronutrients supplements to the status of anemia, and to the status of micronutrients deficiencies of pregnant mothers in West North and High Central areas. Methodology: A community intervention study with placebo group. Pregnant mothers in 40 communes in Lai chau and Kon Tum provinces were divided in control group and placebo group (20 communes for each group). Pregnant mothers in intervention commupes were received micronutrients supplements 1 tablet per day and continue to implement general nutrition activities as nation wide. The placebo communes were having only general nutrition activities as nation wide. Results: At the baseline survey there is no significant difference between 2 groups about mean of hemoglobin, serum ferritin, serum zinc and serum retinol. After invention, concentration of hemoglobin and the micronutrieint in serum were increased in the control group in compare to the placebo group with significant difference. Is was found that the decrease of the prevalence of micronutrient deficiencies in pregnant mothers in control group in compare to the placebo: prevo of low serum ferritin in control group was decreased from 38.8 percent to 7.7 percent. Wherease, in placebo group: the prevo increase from 33.1 percent up to 42 percent. Prevo of Vitamin A deficiency of control group decrease from 16.1 percent dow to 6.2 percent wheareas in the placebo the prevo decrease from 21 percent to 19.5 percent. Prevo of low serum zinc in the control group was decrease from 85 percent dow to 36.6 percent, in compare to the prevo of placebo group is 84.2 percent in the baseline surtvey and increase 87.95 percent in the follow up survey. Conclusion: micronutrients supelements found that contribute to decrease the prevalence of anemia, in combine with increase the concentration of serum iron, zinc and retinol among pregnanat mothers.