Background: Success of heart transplant is one of greatest achievements of organic transplant at Vietnam in the last years. Viet Duc Hospital - the renowned advantages in surgery, it is one of pioneered hospitals in the transplantation especially from brain-death' donor. Since tens of years in the world, general trend is "poly-transplants" from "poly-organic brain-death donor". With 4 successful heart transplantations, Viet Duc Hospital has the greatest heart transplantation amount in country. Analyzing relative factors of these heart transplantation cases, and contribute development of organ transplantation in Vietnam. Method: Prospective describe study: 04 heart transplants from brain dead people for multiple organs from April 2011 to June. Results: Cardiac patIents are receiving males ages 24 to 58, suffering cardiomyopathy dilated terminal. The organ also is men - aged 18 to 37, died of cranial cerebral trauma. Number of transplants and organ donation and are four organs (heart, liver, two kidneys) and two corneas. Human leukocyte antigen (HLA) of donor - recipient get is 2/6 (2 cases) and 1/6 (2 cases), and Crossmach negative. There are 3 transplants the same blood type, a different transplant groups. The process took multiple organ has been perfected gradually in each case, the general order is: dissection of the abdominal organs - the heart dissection - multiple organ protection at the same time - then take heart to the liver and two kidneys, and finally cornea. Organ transplants carried out almost simultaneously. Transplanted heart by two techniques vena cava, aorta clamp. time pairs ranged from 75-85 minutes with a favorable evolution in surgery. Postoperative duration of mechanical ventilation 15 hours maximum, with no postoperative complications as well as transplant rejection, heart transplant function is good, and the patient was discharged within 1 month after surgery. Check periodically checks the heart transplant works well, no expression of rejection. Function and quality of life after transplantation have improved very significantly (from NYHA IV in NYHA I). Condusion: heart transplant surgery can be routinely deployed in Viet Duc Hospital. Need to promote solutions for multi-organ transplant from the maximum power saving organ transplant. You can extend a heart transplant to specify the other heart to bring more opportunities for people with heart disease.