Background: The purpose of this study to be determine the rate of overexpression of Her-2/neu in breast cancer patients. It is also assessement the results of treatment by the 5 years overal survival and disease free survival based on Her-2/neu overexpression. Patients and Methods: This is a retrospective study on 206 breast cancer patients, assessement the survival by Kaplan Meier. Results: Rate of Her-2/neu (+) is 89 cases ER, accounted 43.2 percent and 117 cases Her-2/neu (-) accounted 56.8 percent. There is a strong relationship between the Her-2/neu overexpression and Oestrogen receptor ( p = 0.000), Progesterone receptor( p = 0.000), however, there is no relationship between Her-2/neu overexpression and axillary metastasis status (p = 0.397). Assessement the treatment results shows that the overall survival 5 years as 81.7 percent, the disease free survival 5 years as 90.6 percent for Her-2/neu (-) and 70.6 percent for Her-2/neu (+). There is a difference significant for disease free survival 5 years between axillary lymph node metastasis as 68.2 percent and no metastasis as 93.5 percent (Iogrand, p = 0.033). Condusion: Breast canrer treatment based on overexpression of Her-2/neu is one of most standard method because of bringing the longtime benefit for patients.