Initial test results in laboratory conditions showed that pure juice of the false daisy (Eclipta prostrata L.), guava leaves (Psidium guajava) have antibacterial for Streptococcus spp. and decreased in the dilution rate, which is good antibacterial guava leaves with inhibitory zone 20.63 mm, false daisy has averaged is 12.44 mm. In addition, temperature also affects the antibacterial activity of herbs, guava leaf good reach at 20°C and 35°C, average at 25°C and 30°C, false daisy averaged at 25°C and 30°C, weak at 20°C and 35°C. Guava leaf dose of 300 ml and 400 ml/kg of feed can be good for preventing hybrid sheatfish get disease causing by Streptococcus spp, the survival rate respectively was 83.33 percent and 86.67 percent . Dose of 300 ml/kg of feed get over illiness after 7 days, the survival rate was 50 percent.