Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia.

• Tác giả: Brian S Appleby, Sami Barmada, Brad F Boeve, Adam L Boxer, Andrea Bozoki, David Clark, Yann Cobigo, Kasey Cortez, R Ryan Darby, Bradford C Dickerson, Nico Dimal, Kimiko Domoto-Reilly, Leah K Forsberg, Douglas R Galasko, Daniel H Geschwind, Nupur Ghoshal, Neill R Graff-Radford, Ian M Grant, Hilary Heuer, Lawrence S Honig, Ging-Yuek Robin Hsiung, David Irwin, Kejal Kantarci, Gabriel C Léger, Irene Litvan, Ian R Mackenzie, Joseph C Masdeu, Mario F Mendez, Chiadi U Onyike, Belen Pascual, Peter Pressman, Eliana Marisa Ramos, Erik D Roberson, Emily Rogalski, Howie J Rosen, Maria Carmela Tartaglia, Juan-Camilo Vargas-Gonzalez
• Ngôn ngữ: eng
• Ký hiệu phân loại: 660.65 Genetic engineering
• Thông tin xuất bản: United States : Alzheimer's & dementia : the journal of the Alzheimer's Association , 2025
• Bộ sưu tập: NCBI
• ID: 634017

Tóm tắt

INTRODUCTION: Psychotropic medication (PM) use in behavioral-variant frontotemporal dementia (bvFTD) is higher than in other dementias. However, no information exists on whether PM use differs between sporadic and genetic bvFTD. METHODS: We analyzed data from sporadic and genetic bvFTD participants with PM prescriptions in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects study. We estimated ordinal odds ratio (OOR) of having more PM comparing sporadic and genetic bvFTD. Finally, we explored the neuropsychiatric symptom (NPS) combinations using classification and regression trees (CART). RESULTS: We included 263 with sporadic and 193 with genetic bvFTD. The OOR for sporadic bvFTD to be on PM was 1.75 (95% confidence interval: 1.21 to 2.53) for the fully adjusted model. CART revealed the most common NPS combination was apathy + personality changes in 18% of participants. DISCUSSION: Participants with sporadic bvFTD were twice as likely to be on PM compared to genetic bvFTD. The reason for increased PM usage in sporadic bvFTD participants should be further investigated. HIGHLIGHTS: We report on patients with behavioral variant frontotemporal dementia (bvFTD). We evaluated the psychotropic medication (PM) prescription at baseline in the cohort. Patients with sporadic bvFTD had more prescriptions for PM than genetic patients. The frequency of symptoms combination was different in sporadic and genetic bvFTD.