Pleomorphic adenoma of parapharyngeal space derivated from deep lobe of parotid or ectopic salivary gland. Objective: To find out clinical and imagery characteristics in determining the surgical approach for pleomorphic adenoma of parapharyngeal space. Patients and method: 12 patients with pleomorphic adenoma of parapharyngeal space, diagnosed and operated at ENT Hospital from Dec 2008 to Feb 2011. This was prospective and descriptive study. Results: There were 5 males and 7 females in our study, the average age was 36.6 years old. The most common symptoms was a lump in oropharynx that pushed laterally the tonsils. The dimension the most frequent was from 3 to 6 cm (58.3 percent), 25 percent of tumors was superior to 6 cm. Based on CT and MRI, we stated that 10 tumors derivated from deep lobe of parotid and 2 from ectopic salivary gland. Transcervico-submandibulary approach was performed in 11 cases, the parotidectomy extend approach in 2 cases, no case with endobuccal approach. So far, 1 recurrent after surgery with transcervico-submandibulary approach. Conclusion: CT and MRI had an important role in indentifying the origin of tumors. Surgery with transcervico-submandibulary approach was safe, efficace, least complications. Surgery with transcervico-submandibulary approach was used in case of the bloc of tumors and deep lobe of parotid.