Backgrounds: Demodex mites are tiny arthropoda phylum, arachnida class animal which live off sebum oil and hair follicle. Demodex mites can be found on the skin of humans and animals. In the total of 65 different species, only three species such as Demodex folliculorum, Demodex brevis and Demodex canis can live on human body. Demodex folliculorum and Demodex brevis are the most common permanent ectoparasites in human, occupied around 10 percent skin biopsy or follicles samples (Basta-Juzbasic A et al., 2002). Clinical manifestations presensed of facial erythema, dryness, scaling, and roughness with or without papules/pustules is possibly due to proliferation of these Demodex species. Locations as the scalp, cheeks, nose, eyebrows and even the roots of eyelashes are places where follicle mites live often. Objectives: To highlight this underdiagnosed Demodex spp, disease, the authors describe several clinical epidemiological aspects by patients with skin dermatitis due to Demodex spp. Study methods: Epidemiological cross-sectional study by describe a series of patients from 2006-2012. Results: With total of 118 patients analysis showed a plausible epidemiologic risk model suitable for medical literature. The clinical manifestation included skin or mucocutaneous form similar to symptoms of skin disorders such as rosacea, acne, and scabies. However, some distinctly signs in patients with demodicosis: itching, tickling, and crawling sensation at night. Alopecia, loss of eyelashes, itching of the hair of the head, and itching ears. Conclusions: So far Demodex dermatitis is neglected zoonotic ectoparasite, and researchers have noticed recently an increase in incidence of human demodicosis. Human demodex infestation showed that nonspecific signs and symptoms followed by skin pores and follicles lesions, it is easy to misdiagnosis with other skin problems. Clinicians must be benny noted and have critical thinking in different diagnosis.